Ap1s2^tm1Pschu
Targeted Allele Detail

Summary

• Symbol: Ap1s2^tm1Pschu
• Name: adaptor-related protein complex 1, sigma 2 subunit; targeted mutation 1, Peter Schu
• MGI ID: MGI:5620801
• Synonyms: sigma1B^-
• Gene: Ap1s2 Location: ChrX:162692013-162716662 bp, + strand Genetic Position: ChrX, 75.97 cM, cytoband F5
• Alliance: Ap1s2^tm1Pschu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218588
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of exon 3. This allele targets the sigma1B isoform. Northern-blot analysis confirmed the absence of transcript in mutant mouse embryonic fibroblasts. (J:218588)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ap1s2 Mutation: 7 strains or lines available

References

• Original: J:218588 Glyvuk N, et al., AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J. 2010 Apr 21;29(8):1318-30
• All: 6 reference(s)