Gp6^tm1Beni
Targeted Allele Detail

Summary

• Symbol: Gp6^tm1Beni
• Name: glycoprotein 6 platelet; targeted mutation 1, Bernhard Nieswandt
• MGI ID: MGI:5620877
• Gene: Gp6 Location: Chr7:4366964-4400743 bp, - strand Genetic Position: Chr7, 2.52 cM
• Alliance: Gp6^tm1Beni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217963
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 and intron 2 were partially deleted and a neomycin resistance cassette was inserted and fused to exon 3. Western blot analysis confirmed the absence of protein expression in platelet lysate. (J:217963)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Gp6^tm1Beni/Gp6^tm1Beni	involves: 129 * C57BL/6
cn2	Gp6^tm1Beni/Gp6^tm1Beni Clec1b^tm1.1Arte/Clec1b^tm1.1Arte Tg(Pf4-icre)Q3Rsko/0	involves: 129 * C57BL/6

Phenotypes:

Affected Systems	hm1	cn2
show or hide all annotated terms
hematopoietic system		√
abnormal platelet cell number		√
homeostasis/metabolism	√	√
abnormal blood coagulation	√
increased bleeding time	√	√
immune system		√
abnormal lymphatic vessel morphology		√
reproductive system		√
decreased litter size		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gp6 Mutation: 20 strains or lines available

References

• Original: J:217963 Bender M, et al., Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Arterioscler Thromb Vasc Biol. 2013 May;33(5):926-34
• All: 10 reference(s)