Apc^M1Tno
Chemically induced Allele Detail

Summary

• Symbol: Apc^M1Tno
• Name: APC, WNT signaling pathway regulator; Mutation 1, Tetsuo Noda
• MGI ID: MGI:5620880
• Synonyms: Apc1576
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^M1Tno page

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A point mutation that results in the amino acid substitution of a stop codon for cysteine at position 1576 (Cys1576Ter). (J:218227)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^M1Tno

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:218227 Toki H, et al., Novel mouse model for Gardner syndrome generated by a large-scale N-ethyl-N-nitrosourea mutagenesis program. Cancer Sci. 2013 Jul;104(7):937-44
• All: 1 reference(s)