Nox4^tm1Syb
Targeted Allele Detail

Summary

• Symbol: Nox4^tm1Syb
• Name: NADPH oxidase 4; targeted mutation 1, Yun Soo Bae
• MGI ID: MGI:5620884
• Gene: Nox4 Location: Chr7:86895304-87047918 bp, + strand Genetic Position: Chr7, 48.96 cM
• Alliance: Nox4^tm1Syb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218649
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A floxed neomycin resistance cassette replaced exons 1 and 2. (J:218649)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nox4 Mutation: 68 strains or lines available

References

• Original: J:218649 Lee JH, et al., Interaction of NADPH oxidase 1 with Toll-like receptor 2 induces migration of smooth muscle cells. Cardiovasc Res. 2013 Aug 1;99(3):483-93
• All: 7 reference(s)