Wasl^tm1.1Ttha
Targeted Allele Detail

Summary

• Symbol: Wasl^tm1.1Ttha
• Name: WASP like actin nucleation promoting factor; targeted mutation 1.1, Thirumaran Thanabalu
• MGI ID: MGI:5620949
• Synonyms: N-WASP^fl
• Gene: Wasl Location: Chr6:24613804-24665008 bp, - strand Genetic Position: Chr6, 11.28 cM, cytoband A3
• Alliance: Wasl^tm1.1Ttha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207484
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 3 and 4 floxed. (J:207484)

Disease models

Expression

In Structures Affected by this Mutation:

19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wasl Mutation: 39 strains or lines available

References

• Original: J:207484 Jain N, et al., Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology. Exp Neurol. 2014 Apr;254:29-40
• All: 4 reference(s)