Ndfip1^tm1.1Sest
Targeted Allele Detail

Summary

• Symbol: Ndfip1^tm1.1Sest
• Name: Nedd4 family interacting protein 1; targeted mutation 1.1, Seong-Seng Tan
• MGI ID: MGI:5620967
• Synonyms: Ndfip1^-
• Gene: Ndfip1 Location: Chr18:38551960-38598250 bp, + strand Genetic Position: Chr18, 20.32 cM, cytoband B3
• Alliance: Ndfip1^tm1.1Sest page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212711
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1. (J:212711)

Expression

In Mice Carrying this Mutation:

16 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndfip1 Mutation: 14 strains or lines available

References

• Original: J:212711 Howitt J, et al., Increased Ndfip1 in the substantia nigra of parkinsonian brains is associated with elevated iron levels. PLoS One. 2014;9(1):e87119
• All: 2 reference(s)