Tnfaip3^tm1Homy
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm1Homy
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1, Hiroaki Honda
• MGI ID: MGI:5621002
• Synonyms: A20^flox
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm1Homy page

Inflammation in the lung and liver and destruction of spleen architecture of Tnfaip3^tm1Homy/Tnfaip3^tm1Homy Tg(Mx1-cre)1Cgn/? mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212681
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: Exon 3 was floxed. Flp-mediated recombination removed the neomycin selection cassette inserted downstream of exon 3. (J:212681)

Generation of the Tnfaip3^tm1Homy allele

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 45 strains or lines available

References

• Original: J:212681 Nagamachi A, et al., Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function. PLoS One. 2014;9(1):e87425
• All: 5 reference(s)