Lrp6^tm1Arma
Targeted Allele Detail

Summary

• Symbol: Lrp6^tm1Arma
• Name: low density lipoprotein receptor-related protein 6; targeted mutation 1, Arya Mani
• MGI ID: MGI:5621006
• Synonyms: Lrp6^mut, LRP6^R611C
• Gene: Lrp6 Location: Chr6:134423439-134543876 bp, - strand Genetic Position: Chr6, 65.37 cM
• Alliance: Lrp6^tm1Arma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210538
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Nucleotide substitutions result in the amino acid substitution of cysteine for arginine at position 593 (R593C; the equivalent to the human R611C mutation). (J:210538)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp6 Mutation: 95 strains or lines available

References

• Original: J:210538 Go GW, et al., The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. Cell Metab. 2014 Feb 4;19(2):209-20
• All: 4 reference(s)