Sod3tm1Svp
Targeted Allele Detail
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| Symbol: |
Sod3tm1Svp |
| Name: |
superoxide dismutase 3, extracellular; targeted mutation 1, Steen V Petersen |
| MGI ID: |
MGI:5621017 |
| Synonyms: |
Sod3R213G |
| Gene: |
Sod3 Location: Chr5:52521146-52527080 bp, + strand Genetic Position: Chr5, 27.92 cM
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| Alliance: |
Sod3tm1Svp page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:212043
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| Parent Cell Line: |
iTL BA1 (ES Cell)
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| Strain of Origin: |
(C57BL/6NTac x 129S6/SvEvTac)F1
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| Allele Type: |
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Targeted (Humanized sequence) |
| Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 2 was replaced with one in which a C to G mutation results in the amino acid substitution of arginine with glycine at position 242 (p.R242G on precursor or p.R227G on mature peptide). A loxP site was inserted into intron 1 and a loxP site flanked neomycin resistance gene cassette into intron 2. The mutation mimics a human SNP (p.R231G on precursor or p.R213G on mature peptide) that is associated with susceptibility to cardiovascular and lung disease.
(J:212043, J:285340)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Sod3 Mutation: |
13 strains or lines available
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| Original: |
J:212043 Gottfredsen RH, et al., The cellular distribution of extracellular superoxide dismutase in macrophages is altered by cellular activation but unaffected by the naturally occurring R213G substitution. Free Radic Biol Med. 2014 Apr;69:348-56 |
| All: |
6 reference(s) |
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Analysis Tools
