Fitm2^tm1.1Dls
Targeted Allele Detail

Summary

• Symbol: Fitm2^tm1.1Dls
• Name: fat storage-inducing transmembrane protein 2; targeted mutation 1.1, David L Silver
• MGI ID: MGI:5621176
• Gene: Fitm2 Location: Chr2:163310623-163314549 bp, - strand Genetic Position: Chr2, 84.29 cM
• Alliance: Fitm2^tm1.1Dls page

Reduced amounts of subcutaneous white adipose tissue and epididmyal white adipose tissue in Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Tg(Fabp4-cre)1Rev/? mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212437
• Parent Cell Line: PTL1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the selection cassette and left exon 1 floxed. (J:212437)

Generation of the Fitm2^tm1.1Dls allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fitm2 Mutation: 22 strains or lines available

References

• Original: J:212437 Miranda DA, et al., Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue. J Biol Chem. 2014 Apr 4;289(14):9560-72
• All: 3 reference(s)