Ggcx^tm1Sinos
Targeted Allele Detail

Summary

• Symbol: Ggcx^tm1Sinos
• Name: gamma-glutamyl carboxylase; targeted mutation 1, Satoshi Inoue
• MGI ID: MGI:5621178
• Synonyms: Ggcx^flox
• Gene: Ggcx Location: Chr6:72391291-72407695 bp, + strand Genetic Position: Chr6, 32.27 cM, cytoband C3
• Alliance: Ggcx^tm1Sinos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212951
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. (J:212951)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ggcx Mutation: 37 strains or lines available

References

• Original: J:212951 Azuma K, et al., Liver-specific gamma-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span. PLoS One. 2014;9(2):e88643
• All: 4 reference(s)