Cdh5^tm7Dvst
Targeted Allele Detail

Summary

• Symbol: Cdh5^tm7Dvst
• Name: cadherin 5; targeted mutation 7, Dietmar Vestweber
• MGI ID: MGI:5621267
• Synonyms: VECdelta75
• Gene: Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cdh5^tm7Dvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213676
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: RMCE using Cdh5^tm1Dvst replaced exon 2 and the neomycin resistance cassette with a cDNA lacking the coding sequence for the C-terminal 75 amino acids (VECdelta75), a transcriptional stop site and a hygromycin resistance cassette. (J:213676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh5 Mutation: 59 strains or lines available

Notes

This allele was generated from Cdh5^tm1Dvst.

References

• Original: J:213676 Dartsch N, et al., Fusing VE-cadherin to alpha-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation. Mol Cell Biol. 2014 May;34(9):1634-48
• All: 1 reference(s)