Ercc2^Mhdarco15
Chemically induced Allele Detail

Summary

• Symbol: Ercc2^Mhdarco15
• Name: excision repair cross-complementing rodent repair deficiency, complementation group 2; Martin Hrabe de Angelis reduced coat 15
• MGI ID: MGI:5621284
• Synonyms: RCO015
• Gene: Ercc2 Location: Chr7:19115942-19129619 bp, + strand Genetic Position: Chr7, 9.62 cM
• Alliance: Ercc2^Mhdarco15 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C point mutation that results in the amino acid substitution of proline for serine at position 737 (S737P). Immunohistochemistry detected increased expression in the eye. (J:219404, J:223515)
• Inheritance: Other (see notes)

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ercc2 Mutation: 23 strains or lines available

Notes

Inheritance is dominant per J:219404, but recessive per the Institute of Experimental Genetics, German Research Centre for Environmental Health, Web site (http://www.helmholtz-muenchen.de/en/ieg/groups/genome/enu/mutants.html - no longer live; cached by Google).

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 5 reference(s)