Gt(ROSA)26Sor^{tm1(CAG-MFN2*T105M)Dple}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-MFN2*T105M)Dple}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Pleasure
• MGI ID: MGI:5629288
• Synonyms: Rosa-STOP-MFN2^T105M
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-MFN2*T105M)Dple} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251584
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Gt(ROSA)26Sor^{tm1(CAG-MFN2*T105M)Dple} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MFN2 (9927)

  Mfn2	(MGI:2442230)

• Mutation details: A targeting vector containing a floxed STOP-NEO cassette, a human MFN2 cDNA carrying the T105M mutation, and human growth hormone poly A sequences under the control of the CAG promoter is inserted into the Gt(ROSA)26Sor locus. (J:251584)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:251584 Bannerman P, et al., Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. PLoS One. 2016;11(12):e0167573
• All: 5 reference(s)