Kdm1a^tm1.1Sbae
Targeted Allele Detail

Summary

• Symbol: Kdm1a^tm1.1Sbae
• Name: lysine (K)-specific demethylase 1A; targeted mutation 1.1, Sung Hee Baek
• MGI ID: MGI:5629420
• Synonyms: Lsd1^SA
• Gene: Kdm1a Location: Chr4:136277851-136330034 bp, - strand Genetic Position: Chr4, 68.8 cM
• Alliance: Kdm1a^tm1.1Sbae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210640
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 1 was replaced with one in which nucleotide substitutions (AGC to GCC) results in the amino acid susbtitution of alanine for serine at position 112 (S112A). Cre-mediated recombination removed the loxP- and FRT-flanked puromycin resistance cassette. (J:210640)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm1a Mutation: 39 strains or lines available

References

• Original: J:210640 Nam HJ, et al., Phosphorylation of LSD1 by PKCalpha is crucial for circadian rhythmicity and phase resetting. Mol Cell. 2014 Mar 6;53(5):791-805
• All: 4 reference(s)