Stk31^tm2Jw
Targeted Allele Detail

Summary

• Symbol: Stk31^tm2Jw
• Name: serine threonine kinase 31; targeted mutation 2, Jeremy Wang
• MGI ID: MGI:5629553
• Gene: Stk31 Location: Chr6:49372538-49446435 bp, + strand Genetic Position: Chr6, 23.87 cM
• Alliance: Stk31^tm2Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213823
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neomycin resistance cassette replaced exons 17 through 21, which encodes for part of the kinase domain. Western blot analysis confirmed the absence of protein expression in testes. (J:213823)

Generation of the Stk31^tm2Jw allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk31 Mutation: 53 strains or lines available

References

• Original: J:213823 Zhou J, et al., STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice. PLoS One. 2014;9(2):e89471
• All: 1 reference(s)