Lrit3^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Lrit3^tm1Lex
• Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 3; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5629558
• Synonyms: Lrt3^nob6
• Gene: Lrit3 Location: Chr3:129581530-129597679 bp, - strand Genetic Position: Chr3, 58.99 cM
• Alliance: Lrit3^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214644
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were deleted and replaced by a betageo/puro cassette, with only 21 bp of exon 3 remaining. This was confirmed at the genomic and RNA level. The construct contains a premature stop codon in the first 8 bp of the selection cassette, which is predicted to lead to a truncated 206 amino acid protein lacking presumably the immunoglobulin-like (Ig-like), serine-rich, fibronectin III, transmembrane and PDZ-binding domains. (J:214644)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrit3 Mutation: 25 strains or lines available

References

• Original: J:214644 Neuille M, et al., Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB). PLoS One. 2014;9(3):e90342
• All: 5 reference(s)