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Gng5tm1.1Rbs
Targeted Allele Detail
Summary
Symbol: Gng5tm1.1Rbs
Name: G protein subunit gamma 5; targeted mutation 1.1, Janet D Robishaw
MGI ID: MGI:5629569
Synonyms: Gng5del
Gene: Gng5  Location: Chr3:146205591-146211298 bp, + strand  Genetic Position: Chr3, 71.54 cM
Alliance: Gng5tm1.1Rbs page
Gng5tm1.1Rbs/Gng5tm1.1Rbs mice fail to form the cardiac outflow tract and right ventricle and have severely hypoplastic pharyngeal arches

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:215128
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1. A floxed neomycin resistance cassette was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the selection cassette. RT-PCR confirmed the absence of transcript expression in embryos. (J:215128)
Generation of the Gng5tm1.1Rbs allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gng5 Mutation:  11 strains or lines available
References
Original:  J:215128 Moon AM, et al., Disruption of G-protein gamma5 subtype causes embryonic lethality in mice. PLoS One. 2014;9(3):e90970
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory