Gng5tm1.1Rbs
Targeted Allele Detail
|
Symbol: |
Gng5tm1.1Rbs |
Name: |
G protein subunit gamma 5; targeted mutation 1.1, Janet D Robishaw |
MGI ID: |
MGI:5629569 |
Synonyms: |
Gng5del |
Gene: |
Gng5 Location: Chr3:146205591-146211298 bp, + strand Genetic Position: Chr3, 71.54 cM
|
Alliance: |
Gng5tm1.1Rbs page
|
|
Gng5tm1.1Rbs/Gng5tm1.1Rbs mice fail to form the cardiac outflow tract and right ventricle and have severely hypoplastic pharyngeal arches
Show the 3 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:215128
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
Not Specified
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A loxP site was inserted upstream of exon 1. A floxed neomycin resistance cassette was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the selection cassette. RT-PCR confirmed the absence of transcript expression in embryos.
(J:215128)
|
|
Generation of the Gng5tm1.1Rbs allele |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Gng5 Mutation: |
11 strains or lines available
|
|
Original: |
J:215128 Moon AM, et al., Disruption of G-protein gamma5 subtype causes embryonic lethality in mice. PLoS One. 2014;9(3):e90970 |
All: |
1 reference(s) |
|