Ddhd1^tm1Katn
Targeted Allele Detail

Summary

• Symbol: Ddhd1^tm1Katn
• Name: DDHD domain containing 1; targeted mutation 1, Katsuko Tani
• MGI ID: MGI:5629572
• Synonyms: Ddhd1^{tm1a(KOMP)Katn}, PA-PLA1^G
• Gene: Ddhd1 Location: Chr14:45830628-45895600 bp, - strand Genetic Position: Chr14, 23.14 cM
• Alliance: Ddhd1^tm1Katn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212425
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: The L1L2_gt2 cassette was inserted at position 45854541 of Chromosome 14 upstream of the critical exon 8 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. (J:212425)

Generation of the Ddhd1^tm1Katn and Ddhd1^tm1.1Katn alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ddhd1 Mutation: 41 strains or lines available

References

• Original: J:212425 Baba T, et al., Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. J Biol Chem. 2014 Apr 18;289(16):11497-511
• All: 1 reference(s)