Pou4f2^{tm1.2(cre)Tcba}
Targeted Allele Detail

Summary

• Symbol: Pou4f2^{tm1.2(cre)Tcba}
• Name: POU domain, class 4, transcription factor 2; targeted mutation 1.2, Tudor Constantin Badea
• MGI ID: MGI:5629706
• Synonyms: Brn3b^Cre
• Gene: Pou4f2 Location: Chr8:79159639-79163274 bp, - strand Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
• Alliance: Pou4f2^{tm1.2(cre)Tcba} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215125
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Pou4f2^{tm1.2(cre)Tcba} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pou4f2 (MGI:102524)

• Mutation details: The targeting construct introduced into the 3'UTR three polyadenylation squences, a RoxP site, a cre recombinase gene and an FRT-flanked neomycin resistance cassette. An additional RoxP site was inserted upstream of the translation start site. Flp-mediated recombination removed the selection cassette. Dre-mediated recombination removed the coding sequence and 3 polyadenylation sequence. (J:215125)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pou4f2 (mouse) Summary of all recombinase alleles driven by Pou4f2. Comparative matrix view of recombinase activities Alliance mouse Pou4f2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou4f2 Mutation: 7 strains or lines available

References

• Original: J:215125 Sajgo S, et al., Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice. PLoS One. 2014;9(3):e91435
• All: 2 reference(s)