Yme1l1^tm1Tlan
Targeted Allele Detail

Summary

• Symbol: Yme1l1^tm1Tlan
• Name: YME1-like 1 (S. cerevisiae); targeted mutation 1, Thomas Langer
• MGI ID: MGI:5629742
• Synonyms: Yme1l^loxP
• Gene: Yme1l1 Location: Chr2:23046517-23089272 bp, + strand Genetic Position: Chr2, 15.24 cM
• Alliance: Yme1l1^tm1Tlan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215813
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 3 was floxed and a frt-flanked neo cassette upstream of exon 3 was removed via Flp-mediated recombination. (J:215813, J:229455)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Yme1l1^tm1Tlan/Yme1l1^tm1Tlan Tg(Ckmm-cre)5Khn/0	involves: C57BL/6 * C57BL/6NCrl * FVB
cn2	Oma1^tm1Tlan/Oma1^tm1Tlan Yme1l1^tm1Tlan/Yme1l1^tm1Tlan Tg(Ckmm-cre)5Khn/0	involves: C57BL/6 * C57BL/6NCrl * FVB
cn3  Disease Model	Yme1l1^tm1Tlan/Yme1l1^tm1Tlan Tg(Myh6-cre)2182Mds/0	involves: C57BL/6 * C57BL/6NCrl * FVB/N
cn4	Oma1^tm1Tlan/Oma1^tm1Tlan Yme1l1^tm1Tlan/Yme1l1^tm1Tlan Tg(Myh6-cre)2182Mds/0	involves: C57BL/6 * C57BL/6NCrl * FVB/N

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4
show or hide all annotated terms
cardiovascular system	N		√	N
cardiovascular system phenotype	N			N
cardiac muscle necrosis			√
abnormal heart morphology			√
abnormal myocardial fiber mitochondrial morphology			√
dilated heart left ventricle			√
cardiac fibrosis			√
abnormal cardiovascular system physiology			√
dilated cardiomyopathy			√
increased cardiac muscle cell glucose uptake			√
decreased heart left ventricle muscle contractility			√
congestive heart failure			√
cellular			√
abnormal myocardial fiber mitochondrial morphology			√
increased cardiac muscle cell glucose uptake			√
decreased mitochondrial size			√
abnormal mitochondrial physiology			√
growth/size/body			√
weight loss			√
homeostasis/metabolism	√	N	√
homeostasis/metabolism phenotype		N
decreased circulating insulin level	√
increased circulating troponin T level			√
impaired glucose tolerance	√
mortality/aging	N		√
mortality/aging	N
premature death			√
muscle			√
abnormal myocardial fiber mitochondrial morphology			√
cardiac muscle necrosis			√
abnormal muscle physiology			√
dilated cardiomyopathy			√
increased cardiac muscle cell glucose uptake			√
decreased heart left ventricle muscle contractility			√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn3
dilated cardiomyopathy IDs dilated cardiomyopathy       DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193 Close	√

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yme1l1 Mutation: 59 strains or lines available

References

• Original: J:215813 Anand R, et al., The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol. 2014 Mar 17;204(6):919-29
• All: 7 reference(s)