Slurp1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Slurp1^tm1Lex
• Name: secreted Ly6/Plaur domain containing 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5629821
• Gene: Slurp1 Location: Chr15:74598493-74599872 bp, - strand Genetic Position: Chr15, 34.26 cM
• Alliance: Slurp1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210836
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with lacZ and neo cassettes. Beta-galactosidase is not expressed. Western blot analysis confirmed absence of protein expression in extracts of paw skin. Expression of two genes adjacent to Slurp1, Slurp2 and Lypd2, are reduced by 60-70% in homozygous mice. (J:210836)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slurp1 Mutation: 16 strains or lines available

References

• Original: J:210836 Adeyo O, et al., Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. J Invest Dermatol. 2014 Jun;134(6):1589-98
• All: 2 reference(s)