Slurp1^tm1.1Sgy
Targeted Allele Detail

Summary

• Symbol: Slurp1^tm1.1Sgy
• Name: secreted Ly6/Plaur domain containing 1; targeted mutation 1.1, Stephen G Young
• MGI ID: MGI:5629843
• Synonyms: Slurp1X^-
• Gene: Slurp1 Location: Chr15:74598493-74599872 bp, - strand Genetic Position: Chr15, 34.26 cM
• Alliance: Slurp1^tm1.1Sgy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210836
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A premature stop codon (N35X) was introduced into exon 2. The loxP flanked neo cassette inserted downstream from from the polyadenylation signal was removed via cre-mediated recombination. Expression of the adjacent genes, Slurp2 and Lypd2, are not reduced as is seen in the Slurp1^tm1Sgy allele. (J:210836)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slurp1 Mutation: 16 strains or lines available

References

• Original: J:210836 Adeyo O, et al., Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. J Invest Dermatol. 2014 Jun;134(6):1589-98
• All: 4 reference(s)