Mir34a^tm2.1Hher
Targeted Allele Detail

Summary

• Symbol: Mir34a^tm2.1Hher
• Name: microRNA 34a; targeted mutation 2.1, Heiko Hermeking
• MGI ID: MGI:5629848
• Synonyms: mir-34a^loxP
• Gene: Mir34a Location: Chr4:150152911-150153012 bp, + strand Genetic Position: Chr4, 80.85 cM
• Alliance: Mir34a^tm2.1Hher page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175978
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the microRNA. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the microRNA. Flp-mediated recombination remoced the selection cassette and left the microRNA floxed. This allele was used to generate Mir34a^tm1Hher. (J:175978)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir34a Mutation: 9 strains or lines available

References

• Original: J:175978 Hwang CI, et al., Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14240-5
• All: 5 reference(s)