Pagr1a^tm1Kaig
Targeted Allele Detail

Summary

• Symbol: Pagr1a^tm1Kaig
• Name: PAXIP1 associated glutamate rich protein 1A; targeted mutation 1, Kai Ge
• MGI ID: MGI:5629850
• Synonyms: Pagr1a^-
• Gene: Pagr1a Location: Chr7:126614223-126616524 bp, - strand Genetic Position: Chr7, 69.27 cM, cytoband F4
• Alliance: Pagr1a^tm1Kaig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210984
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1 and 2 were deleted. Whole-mount in situ hybridization confirmed absence of expression in a homozygous mutant embryo at the late allantoic bud stage/early head fold stage. Absence of detectable mRNA corresponding to exon 3, which is retained in the deleted allele, may be due either to lack of transcription initiation or to mRNA instability, suggesting that the allele is a complete null. (J:210984)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pagr1a Mutation: 15 strains or lines available

References

• Original: J:210984 Kumar A, et al., Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development. Dev Dyn. 2014 Jul;243(7):937-47
• All: 1 reference(s)