Nxf1^em1Haml
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nxf1^em1Haml
• Name: nuclear RNA export factor 1; endonuclease-mediated mutation 1, Bruce Hamilton
• MGI ID: MGI:5629959
• Synonyms: Nxf1[E610G]
• Gene: Nxf1 Location: Chr19:8734467-8748274 bp, + strand Genetic Position: Chr19, 5.5 cM, cytoband A
• Alliance: Nxf1^em1Haml page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-mediated mutagenesis introduced a two nucleotide change resulting in a non-synonymous substitution Glu610Gly (GAG to GGG) and a silent substitution in Glu613 (GAA to GAG). (J:219914)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nxf1 Mutation: 36 strains or lines available

References

• Original: J:219914 Concepcion D, et al., Nxf1 Natural Variant E610G Is a Semi-dominant Suppressor of IAP-Induced RNA Processing Defects. PLoS Genet. 2015 Apr;11(4):e1005123
• All: 1 reference(s)