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Poc1atm1.1(KOMP)Mbp
Targeted Allele Detail
Summary
Symbol: Poc1atm1.1(KOMP)Mbp
Name: POC1 centriolar protein A; targeted mutation 1.1, Mouse Biology Program, UC Davis
MGI ID: MGI:5630068
Gene: Poc1a  Location: Chr9:106158260-106227720 bp, + strand  Genetic Position: Chr9, 57.46 cM, cytoband F1
Alliance: Poc1atm1.1(KOMP)Mbp page
IMPC: Poc1a gene page
Mutation
origin
Mutant Cell Line:  DEPD00572_5_B12
Germline Transmission:  Earliest citation of germline transmission: J:204739
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsCre-mediated excision of the parental Poc1atm1(KOMP)Mbp allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
DEPD00572_5_B12
DEPD00572_5_B12
Phenotypes:
Affected Systems
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Source:
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IMPC - JAX
IMPC - JAX
IMPC - JAX
IMPC - JAX
homeostasis/metabolism
decreased fasting circulating glucose level
increased urine microalbumin level
mortality/aging
preweaning lethality, incomplete penetrance
renal/urinary system
increased urine microalbumin level
reproductive system
female infertility
male infertility
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Poc1a Mutation:  18 strains or lines available
References
Original:  J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory