Poc1a^{tm1.1(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Poc1a^{tm1.1(KOMP)Mbp}
• Name: POC1 centriolar protein A; targeted mutation 1.1, Mouse Biology Program, UC Davis
• MGI ID: MGI:5630068
• Gene: Poc1a Location: Chr9:106158260-106227720 bp, + strand Genetic Position: Chr9, 57.46 cM, cytoband F1
• Alliance: Poc1a^{tm1.1(KOMP)Mbp} page
• IMPC: Poc1a gene page

Mutation origin

• Mutant Cell Line: DEPD00572_5_B12
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Poc1a^tm1(KOMP)Mbp allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Poc1a^tm1.1(KOMP)Mbp/Poc1a^tm1.1(KOMP)Mbp	C57BL/6N-Poc1a^tm1.1(KOMP)Mbp/J	DEPD00572_5_B12
ht2	Poc1a^tm1.1(KOMP)Mbp/Poc1a^+	C57BL/6N-Poc1a^tm1.1(KOMP)Mbp/J	DEPD00572_5_B12

Phenotypes:

Affected Systems	hm1		ht2
show or hide all annotated terms Sex:
Source:	IMPC - JAX	IMPC - JAX	IMPC - JAX	IMPC - JAX
homeostasis/metabolism			√	√
decreased fasting circulating glucose level			√	√
increased urine microalbumin level				√
mortality/aging	√	√
preweaning lethality, incomplete penetrance	√	√
renal/urinary system				√
increased urine microalbumin level				√
reproductive system	√	√
female infertility	√
male infertility		√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Poc1a Mutation: 18 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 3 reference(s)