Tlr9^M9Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr9^M9Btlr
• Name: toll-like receptor 9; mutation 9, Bruce Beutler
• MGI ID: MGI:5632141
• Synonyms: Asura
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^M9Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: The mutation is a T to C transition at base pair 106,224,647 (Build 38) on Chromosome 9, or base pair 2,050 in the GenBank genomic region NC_000075, in the second of the gene's two exons; this corresponds to nucleotide 1,242 in the mRNA sequence NM_031178. The mutation results in a leucine (L) to proline (P) substitution at amino acid position 379 (L379P) of the protein. (J:220063)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 66 strains or lines available

References

• Original: J:220063 Sun L, et al., Mutagenetix entry for Asura (Last updated March 25, 2015). MGI Direct Data Submission. 2015
• All: 1 reference(s)