Il22^{tm1.1(icre)Stck}
Targeted Allele Detail

Summary

• Symbol: Il22^{tm1.1(icre)Stck}
• Name: interleukin 22; targeted mutation 1.1, Brigitta Stockinger
• MGI ID: MGI:5632146
• Synonyms: IL22^Cre
• Gene: Il22 Location: Chr10:118040847-118045952 bp, + strand Genetic Position: Chr10, 66.67 cM
• Alliance: Il22^{tm1.1(icre)Stck} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220074
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Il22^{tm1.1(icre)Stck} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Il22 (MGI:1355307)

• Mutation details: A targeting construct was designed to replace exon 1 of the Il22 (interleukin 22) gene with a 6 aa linker sequence, a codon improved Cre Recombinase gene (iCre) followed by an SV40 polyadenylation sequence and a FRT-flanked neomycin resistance (neo) cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:220074)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Il22 (mouse) Summary of all recombinase alleles driven by Il22. Comparative matrix view of recombinase activities Alliance mouse Il22 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il22 Mutation: 29 strains or lines available

References

• Original: J:220074 Ahlfors H, et al., IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection. J Immunol. 2014 Nov 1;193(9):4602-13
• All: 18 reference(s)