Lyst^bg-6Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lyst^bg-6Btlr
• Name: lysosomal trafficking regulator; beige 6 Bruce Beutler
• MGI ID: MGI:5632154
• Synonyms: lightspeed
• Gene: Lyst Location: Chr13:13764982-13953388 bp, + strand Genetic Position: Chr13, 5.28 cM
• Alliance: Lyst^bg-6Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a T to C transition at base pair 13,740,536 (Build 38) on Chromosome 13, or base pair 150,198 in the GenBank genomic region NC_000079, within exon 43 of the gene's 53 total exons; this corresponds to nucleotide 9,995 in the mRNA sequence NM_178666. The mutation results in a serine (S) to proline (P) substitution at amino acid position 3272 (S3272P) of the protein. (J:220065)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Lyst^bg-6Btlr/Lyst^bg-6Btlr	C57BL/6J-Lyst^bg-6Btlr

Phenotypes:

Affected Systems	hm1
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immune system	√
increased susceptibility to Herpesvirales infection	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyst Mutation: 227 strains or lines available

References

• Original: J:220065 Zhang D, et al., Mutagenetix entry for lightspeed. (Last updated March 25, 2015). MGI Direct Data Submission. 2015
• All: 1 reference(s)