Tnfsf13b^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tnfsf13b^M1Btlr
• Name: tumor necrosis factor (ligand) superfamily, member 13b; mutation 1, Bruce Beutler
• MGI ID: MGI:5632166
• Synonyms: Frozen
• Gene: Tnfsf13b Location: Chr8:10056637-10086000 bp, + strand Genetic Position: Chr8, 4.55 cM
• Alliance: Tnfsf13b^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a T-to-A transversion at base pair 10,031,661 (Build GRCm38) on Chromosome 8, or base pair 25,469 in the GenBank genomic region NC_000074, within the donor splice site of intron 6. The effects of the mutation at the cDNA and protein levels have not been examined, but it is predicted to result in skipping of the 151-nucleotide exon 6 (out of 7 total exons) leading to a frame-shift that results in coding of 34 aberrant amino acids followed by a premature stop codon. (J:220069)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf13b Mutation: 30 strains or lines available

References

• Original: J:220069 Choi JH, et al., Mutagenetix entry for Frozen (Last updated April 17, 2015). MGI Direct Data Submission. 2015;v
• All: 2 reference(s)