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Hipk4tm1b(KOMP)Mbp
Targeted Allele Detail
Summary
Symbol: Hipk4tm1b(KOMP)Mbp
Name: homeodomain interacting protein kinase 4; targeted mutation 1b, Mouse Biology Program, UC Davis
MGI ID: MGI:5632532
Synonyms: Hipk4-
Gene: Hipk4  Location: Chr7:27222692-27230600 bp, + strand  Genetic Position: Chr7, 15.92 cM
Alliance: Hipk4tm1b(KOMP)Mbp page
IMPC: Hipk4 gene page
Mutation
origin
Mutant Cell Line:  DEPD0005_5_G07
Germline Transmission:  Earliest citation of germline transmission: J:204739
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsCre-mediated excision of the parental Hipk4tm1a(KOMP)Mbp allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exons (exons 2 and 3) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. PCR of tail-derived genomic DNA and Western blot analyses of whole testis lysates confirmed the absence of functional gene products in homozygous male mice. (J:204739, J:290279)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hipk4 Mutation:  19 strains or lines available
References
Original:  J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory