Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps
Transgene Detail

Summary

• Symbol: Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps
• Name: transgene insertion, David M Spencer
• MGI ID: MGI:5633960
• Synonyms: Ubi-Cat
• Transgene: Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps Location: unknown
• Alliance: Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Fkbp1a
  Not Specified	Lrp5

• Mutation details: The H-2K^b promoter drives expression of the cytoplasmic portion of Lrp5 fused to two tandem AP20187 drug binding domains for chemically induced dimerization and the click beetle red-shifted luciferase gene. qRT-PCR confirmed expression of the transgene in multiple tissues of adults, with highest expression in the pancreas, followed by testes, mammary gland, spleen and prostate. (J:184212)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:184212 Shahi P, et al., Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis. PLoS One. 2012;7(1):e30814
• All: 2 reference(s)