Prlh^tm1(cre)Smln
Targeted Allele Detail

Summary

• Symbol: Prlh^tm1(cre)Smln
• Name: prolactin releasing hormone; targeted mutation 1, Simon M Luckman
• MGI ID: MGI:5634277
• Synonyms: PrRP-Cre
• Gene: Prlh Location: Chr1:90880830-90881749 bp, + strand Genetic Position: Chr1, 45.81 cM
• Alliance: Prlh^tm1(cre)Smln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215557
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Prlh^tm1(cre)Smln expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prlh (MGI:3644668)

• An IRES-cre was inserted downstream of the endogenous STOP codon in exon 2. (J:215557)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prlh (mouse) Summary of all recombinase alleles driven by Prlh. Comparative matrix view of recombinase activities Alliance mouse Prlh gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prlh Mutation: 7 strains or lines available

References

• Original: J:215557 Dodd GT, et al., The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab. 2014 Oct 7;20(4):639-49
• All: 2 reference(s)