Prlh^tm2Smln
Targeted Allele Detail

Summary

• Symbol: Prlh^tm2Smln
• Name: prolactin releasing hormone; targeted mutation 2, Simon M Luckman
• MGI ID: MGI:5634278
• Synonyms: LSL-PrRP
• Gene: Prlh Location: Chr1:90880830-90881749 bp, + strand Genetic Position: Chr1, 45.81 cM
• Alliance: Prlh^tm2Smln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215557
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed STOP and neomycin resistance cassette were inserted upstream of the endogenous gene. Immunostaining confirmed the absence of protein expression in the brain. (J:215557)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prlh Mutation: 7 strains or lines available

References

• Original: J:215557 Dodd GT, et al., The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab. 2014 Oct 7;20(4):639-49
• All: 1 reference(s)