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Tg(Eno2-APP*Ind,-PSEN1*P267S)#Kakiz
Transgene Detail
Summary
Symbol: Tg(Eno2-APP*Ind,-PSEN1*P267S)#Kakiz
Name: transgene insertion, Akira Kakizuka
MGI ID: MGI:5634331
Synonyms: V717F/P267S
Transgene: Tg(Eno2-APP*Ind,-PSEN1*P267S)#Kakiz  Location: unknown  
Alliance: Tg(Eno2-APP*Ind,-PSEN1*P267S)#Kakiz page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsTwo transgenes, one expressing a FLAG-tagged beta-c-terminal fragment of human APP with the Indiana mutation (V717F), and another with an HA-tagged full-length presenilin with the P267S mutation, both under the control of the neuron-specific enolase promoter were coinjected to generate the transgenic mice. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:212692)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:212692 Sasaoka N, et al., Long-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in mice. PLoS One. 2014;9(1):e87185
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory