Tg(Sox10-icre/ERT2)388Wdr
Transgene Detail

Summary

• Symbol: Tg(Sox10-icre/ERT2)388Wdr
• Name: transgene insertion 388, William D Richardson
• MGI ID: MGI:5634390
• Synonyms: Sox10-iCreER^T2, Tg(Sox10-icre/ERT2)#aWdr
• Transgene: Tg(Sox10-icre/ERT2)388Wdr Location: unknown
• Alliance: Tg(Sox10-icre/ERT2)388Wdr page

Transgene origin

• Strain of Origin: C57BL/6 or CBA

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Sox10-icre/ERT2)388Wdr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox10 (MGI:98358)

• Mutation details: The transgene was generated using the PAC RP21-427F18. Oligodendrocyte-specific expression of the inducible improved cre recombinase (icre/ERT2) was achieved by replacing the coding sequence of Sox10 with the fusion. Four founders were obtained and one (388) was selected for further study. (J:217432)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox10 (mouse) Summary of all recombinase alleles driven by Sox10. Comparative matrix view of recombinase activities Alliance mouse Sox10 gene page

Tumor Data

List all tumor models in MMHCdb carrying Tg(Sox10-icre/ERT2)388Wdr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:217432 McKenzie IA, et al., Motor skill learning requires active central myelination. Science. 2014 Oct 17;346(6207):318-22
• All: 26 reference(s)