Tg(tetO-Mtor*)#Atai
Transgene Detail

Summary

• Symbol: Tg(tetO-Mtor*)#Atai
• Name: transgene insertion, Atsu Aiba
• MGI ID: MGI:5634714
• Synonyms: TRE-mTOR^SL1+IT
• Transgene: Tg(tetO-Mtor*)#Atai Location: unknown
• Alliance: Tg(tetO-Mtor*)#Atai page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(tetO-Mtor*)#Atai expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Mtor (56718)

  Mtor	(MGI:1928394)

• Mutation details: This transgene consists of the tetracycline-responsive element and the mutant rat Mtor kinase, which harbors four point mutations in the FKBP12-rapamycin binding and kinase domains (V2198A, L2216H, L2260P, and I2017T) with a FLAG tag at the N terminus. Expression of active Mtor depends on binding of tTA to the tetO promoter. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:211789)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:211789 Kassai H, et al., Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014 Jun 12;7(5):1626-39
• All: 2 reference(s)