Tg(Thy1-EGFP/SQSTM1*P392L)#Mcwo
Transgene Detail

Summary

• Symbol: Tg(Thy1-EGFP/SQSTM1*P392L)#Mcwo
• Name: transgene insertion, Michael Wooten
• MGI ID: MGI:5634938
• Synonyms: p62:P392L
• Transgene: Tg(Thy1-EGFP/SQSTM1*P392L)#Mcwo Location: unknown
• Alliance: Tg(Thy1-EGFP/SQSTM1*P392L)#Mcwo page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutations: Insertion, Nucleotide substitutions
• Tg(Thy1-EGFP/SQSTM1*P392L)#Mcwo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SQSTM1 (8878)

  Sqstm1

  (MGI:107931)

• Mutation details: The transgenic construct includes an EFGP translation initiation codon, signal peptide and human SQSTM1 (p62) with a P392L substitution, translation initiation codon, signal peptide, termination codon and polyA tail. The 97 kD fusion protein is under the control of the Thy1.2 promoter. Expression is detected mainly in the hippocampal region of the brain and to a lesser extent in the brain stem, striatum, and cortex. (J:198513)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:198513 Seibenhener ML, et al., Behavioral effects of SQSTM1/p62 overexpression in mice: support for a mitochondrial role in depression and anxiety. Behav Brain Res. 2013 Jul 1;248:94-103
• All: 1 reference(s)