Fosb^tm2.1Yun
Targeted Allele Detail

Summary

• Symbol: Fosb^tm2.1Yun
• Name: FBJ osteosarcoma oncogene B; targeted mutation 2.1, Yusaku Nakabeppu
• MGI ID: MGI:5634957
• Synonyms: fosB^G
• Gene: Fosb Location: Chr7:19036621-19043970 bp, - strand Genetic Position: Chr7, 9.56 cM, cytoband A2-B1
• Alliance: Fosb^tm2.1Yun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220448
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A destabilized variant of the enhanced green fluorescent protein (EGFP) was inserted in frame in exon 2 and the remainder of exon 2 and all of exon 3 were replaced by a floxed neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. (J:220449)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fosb Mutation: 22 strains or lines available

References

• Original: J:220449 Ohnishi YN, et al., Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol Biol Cell. 2008 Nov;19(11):4717-29
• All: 4 reference(s)