Mpc2^em2Finc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mpc2^em2Finc
• Name: mitochondrial pyruvate carrier 2; endonuclease-mediated mutation 2, Brian Finck
• MGI ID: MGI:5635078
• Synonyms: Mpc2^delta16
• Gene: Mpc2 Location: Chr1:165288829-165308787 bp, + strand Genetic Position: Chr1, 72.8 cM, cytoband H2
• Alliance: Mpc2^em2Finc page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: Zinc finger targeted endonuclease technology generated a 20 bp deletion at the N-terminus that included the original start codon. mRNA expression level is normal but a truncated protein that lacked the first 16 amino acids residues was produced. (J:211781)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpc2 Mutation: 16 strains or lines available

References

• Original: J:211781 Vigueira PA, et al., Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell Rep. 2014 Jun 26;7(6):2042-53
• All: 2 reference(s)