Tg(HTT*)NXwy
Transgene Detail
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Symbol: |
Tg(HTT*)NXwy |
Name: |
transgene insertion N, X William Yang |
MGI ID: |
MGI:5635152 |
Synonyms: |
BACHD-deltaN17 |
Transgene: |
Tg(HTT*)NXwy Location: unknown
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Alliance: |
Tg(HTT*)NXwy page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(HTT*)NXwy expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
HTT (3064) |
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Expresses a BAC with the first 17 amino acids deleted and exon 1 recplaced with 97 CAA-CAG repeats |
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Mutation details: The 240 kb human bacterial artificial chromosome (BAC RP11-866L6), containing the entire 170 kb human Huntingtin genomic locus and approximately 20 kbp of 5' and 50 kbp of 3' flanking sequences and modified to replace the human HTT exon 1 with a loxP-flanked human mutant HTT exon 1 sequence containing 97 mixed CAA-CAG repeats encoding a continuous polyglutamine stretch was further modified to delete the first 17-amino-acid domain (N17; residues 2-16). This modified BAC containing both the 97Q and the deleted N17 domain was microinjected into FVB/NJ fertilized eggs. Three founders were established; N, L, and A. Line N and L show a similar level of expression.
(J:219890)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:219890 Gu X, et al., N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice. Neuron. 2015 Feb 18;85(4):726-41 |
All: |
2 reference(s) |
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