Tnnt1^tm1Jin
Targeted Allele Detail

Summary

• Symbol: Tnnt1^tm1Jin
• Name: troponin T1, skeletal, slow; targeted mutation 1, Jian-Ping Jin
• MGI ID: MGI:5635254
• Synonyms: ssTnT-KD, Tnnt1-neo-flox
• Gene: Tnnt1 Location: Chr7:4507568-4518974 bp, - strand Genetic Position: Chr7, 2.6 cM
• Alliance: Tnnt1^tm1Jin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219907
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into intron 10 and intron 13. A FRT-flanked neomycin resistance cassette was inserted into intron 10. Western blot analysis confirmed a significant reduction in protein expression in the soleus muscle. (J:219907)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnnt1 Mutation: 4 strains or lines available

References

• Original: J:219907 Wei B, et al., Deficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigue. J Physiol. 2014 Mar 15;592(Pt 6):1367-80
• All: 1 reference(s)