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Ip6k2tm1.1Snyd
Targeted Allele Detail
Summary
Symbol: Ip6k2tm1.1Snyd
Name: inositol hexaphosphate kinase 2; targeted mutation 1.1, Solomon Snyder
MGI ID: MGI:5635272
Synonyms: Ip6k2-
Gene: Ip6k2  Location: Chr9:108660995-108683536 bp, + strand  Genetic Position: Chr9, 59.63 cM, cytoband F2
Alliance: Ip6k2tm1.1Snyd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212482
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 6. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. Cre-mediated recombination removed exon 6 and the selection cassette. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:212482)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ip6k2 Mutation:  26 strains or lines available
References
Original:  J:212482 Rao F, et al., Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell. 2014 Apr 10;54(1):119-32
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory