Tg(HLA-DRA,HLA-DRB5*0101)loKito
Transgene Detail
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Symbol: |
Tg(HLA-DRA,HLA-DRB5*0101)loKito |
Name: |
transgene insertion lo, Kouichi Ito |
MGI ID: |
MGI:5635431 |
Synonyms: |
DR2alo |
Transgene: |
Tg(HLA-DRA,HLA-DRB5*0101)loKito Location: unknown
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Alliance: |
Tg(HLA-DRA,HLA-DRB5*0101)loKito page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(HLA-DRA,HLA-DRB5*0101)loKito expresses
4 genes
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
mouse |
H2-Ea (MGI:95900) |
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Expresses a human HLA-DRA and HLA-DRB5*01:01 fused to mouse H2-Ea-ps and H2-EB1 |
mouse |
H2-Eb1 (MGI:95901) |
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Expresses a human HLA-DRA and HLA-DRB5*01:01 fused to mouse H2-Ea-ps and H2-EB1 |
human |
HLA-DRA (3122) |
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Expresses a human HLA-DRA and HLA-DRB5*01:01 fused to mouse H2-Ea-ps and H2-EB1 |
human |
HLA-DRB5 (3127) |
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Expresses a human HLA-DRA and HLA-DRB5*01:01 fused to mouse H2-Ea-ps and H2-EB1 |
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Mutation details: A chimeric MHC class II complex was created by fusing the human peptide antigen binding domains of class II alpha and beta chains (HLA-DRA and HLA-DRB5*01:01) to the remaining domains of murine class II alpha or beta chains (H2-Ea-ps and H2-Eb1 genes that make up mouse I-Ed). The chimeric gene constructs were manipulated by replacing exon 2 of IEd-alpha or IEd-beta genomic DNA with gene fragments containing exon 2 of HLA-DRA or HLA-DRB5*01:01, respectively. The native murine promoters were left intact. Two lines were created, a high expressing line (hi) and a low expressing line (lo).
(J:189816)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:189816 Quandt JA, et al., Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis. J Immunol. 2012 Sep 15;189(6):2897-908 |
All: |
1 reference(s) |
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