Tg(tetO-GJB2*G45E,-EGFP)#Tww
Transgene Detail

Summary

• Symbol: Tg(tetO-GJB2*G45E,-EGFP)#Tww
• Name: transgene insertion, Thomas W White
• MGI ID: MGI:5635524
• Synonyms: TRE-G45E
• Transgene: Tg(tetO-GJB2*G45E,-EGFP)#Tww Location: unknown
• Alliance: Tg(tetO-GJB2*G45E,-EGFP)#Tww page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-GJB2*G45E,-EGFP)#Tww expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GJB2 (2706)

  Gjb2	(MGI:95720)

• Mutation details: The human GJB2 coding sequence with the G45E mutation, an IRES, and EGFP are under the control of the tetracycline-responsive promoter (TRE-minCMV). The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:220589)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:220589 Mese G, et al., The Cx26-G45E mutation displays increased hemichannel activity in a mouse model of the lethal form of keratitis-ichthyosis-deafness syndrome. Mol Biol Cell. 2011 Dec;22(24):4776-86
• All: 5 reference(s)