Bhr7^A/J
QTL Variant Detail

Summary

• QTL variant: Bhr7^A/J
• Name: bronchial hyperresponsiveness 7; A/J
• MGI ID: MGI:5635629
• QTL: Bhr7 Location: Chr6:115219814-115219938 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:59047

QTL mapping was performed on 369 animals from a (A/J X C3H/HeJ)F1 X C3H/HeJ backcross population to detect loci associated with methacholine-induced airway hyperresponsiveness, a phenotype similar to asthma in humans. 81-97 polymorphic markers at an average resolution of 15 cM were typed in 232 phenotypically extreme backcross animals. Parental strain A/J exhibits greater airway responsiveness when challenged with methacholine compared to parental strain C3H/HeJ. (A/J X C3H/HeJ)F1 animals exhibit an intermediate phenotype skewed towards the A/J phenotype.

Bhr5, a QTL on mouse Chromosome 6 previously identified by Ewart et al (J:33778) was detected and confirmed. In the present study Bhr5 mapped to 55 cM - 95 cM with a LOD score of 3.32 at D6Mit366.

02.09.2015 Curators Note: Because Bhr5 was originally mapped in Ewart et al (J:33778) using the same strains but the mapping backcross was performed in the opposite direction, (C3H/HeJ x A/J)F1 x A/J, we consider this a separate mapping experiment and have named the QTL identified in this study as Bhr7.

A novel locus, Bhr6, mapped to mouse Chromosome 7 from 0 cM - 30 cM with a LOD score of 3.8 at D7Mit247. A possible candidate gene for Bhr6 is Klk, the kallikrein gene. Standard ANOVA analysis did not detect interaction between Bhr5 and Bhr6.

A suggestive locus mapped to mouse Chromosome 17 at 23.3 cM (LOD = 1.7 at D17Mit215).

References

• Original: J:59047 De Sanctis GT, et al., Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. Am J Physiol. 1999 Dec;277(6 Pt 1):L1118-23
• All: 1 reference(s)