Bw21^AKR/J
QTL Variant Detail

Summary

• QTL variant: Bw21^AKR/J
• Name: body weight QTL 21; AKR/J
• MGI ID: MGI:5635707
• QTL: Bw21 Location: Chr19:56596066-56596066 bp Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: AKR/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:106112

QTLs associated with atherosclerosis susceptibility on a CHOW diet were mapped in 209 (DBA/2J-Apoe^tm1Bres x AKR/J-Apoe^tm1Bres)F2 animals. Linkage analysis was performed using 1967 single nucleotide polymorphic (SNP) markers.

A number of Body weight QTL were also discovered.

Bw20 mapped to 34 cM (LOD 5.1) on mouse Chr12 peaking at marker rs3662628 with the heterzygous phenotype conferring the highest body weight;

Bw21 mapped to 45 cM (LOD 3.7) on mouse Chr19 peaking at marker rs3023497 with the AKR/J allele conferring the highest body weigth in an additive mode of inheritance.

Bw22 and Bw25 mapped to Chr2 in males at 58 cM (rs13476656) and at 70 cM (rs13476754) in males and females . The Chr 2 QTLs may represent the same locus. Bw22 and Bw25 had LODs scores of 3.17 and 4.17 respectively. The AKR/J alleles conferred higher body weight at both loci.

References

• Original: J:106112 Smith JD, et al., Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):597-603
• All: 1 reference(s)