Zfp521^tm1Nohk
Targeted Allele Detail

Summary

• Symbol: Zfp521^tm1Nohk
• Name: zinc finger protein 521; targeted mutation 1, Nobutaka Ohkubo
• MGI ID: MGI:5635813
• Synonyms: ZFP521^delta
• Gene: Zfp521 Location: Chr18:13820070-14105812 bp, - strand Genetic Position: Chr18, 7.68 cM
• Alliance: Zfp521^tm1Nohk page

Small body size of Zfp521^tm1Nohk/Zfp521^tm1Nohk mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neomycin resistance cassette replaced most of exon 4. An in-frame stop codon was additionally inserted downstream of the remainder of exon 4. This deletion caused a loss of zinc finger motifs ZF2 to ZF30, among which the ZF9 to ZF30 motifs are required for neuralizing activity. Northern blot analysis confirmed the absence of transcript expression in the brain. (J:214267)

Generation of the Zfp521^tm1Nohk allele

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp521 Mutation: 51 strains or lines available

References

• Original: J:214267 Ohkubo N, et al., Abnormal behaviors and developmental disorder of hippocampus in zinc finger protein 521 (ZFP521) mutant mice. PLoS One. 2014;9(3):e92848
• All: 2 reference(s)