Hbnr12^CBA
QTL Variant Detail

Summary

• QTL variant: Hbnr12^CBA
• Name: Heligmosomoides bakeri nematode resistance 12; CBA
• MGI ID: MGI:5635862
• QTL: Hbnr12 Location: Chr8:33277016-51290537 bp Genetic Position: Chr8, Syntenic

Variant origin

• Strain of Specimen: CBA

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:160808

Linkage analysis was originally performed on an (SWR x CBA)F2 intercross population to identify loci affecting resistance/susceptibility to infection by the nematode Heligmosomoides polygyrus. Parental strain SWR is resistant to nematode infection whereas CBA is susceptible. The authors indicate that the mice analyzed in this report were from both the original F2 resource (516 mice) and an additional F6/7 resource(1100 mice). By using these crosses seven additional QTLs were detected by the authors ( in parenthesis is the mouse Chromosome, peak linked STS marker and a physical range in Mb): Hbnr9(Chr 5. D5Mit81, 40Mb-60Mb) , Hbnr10(Chr 5. D5Mit259, 74Mb-98Mb) , Hbnr11(Chr 8. D8Mit195, 74Mb-97Mb) , Hbnr12(Chr 8. D8Mit64-D8Mit205, 34Mb-52Mb) , Hbnr13(Chr 11. D11Mit296, 33Mb-53Mb) , Hbnr14(Chr 11. D11Mit10, 104Mb-122Mb) , Hbnr15(Chr 11. D11Mit227, 7Mb-27Mb) .

References

• Original: J:160808 Behnke JM, et al., Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice. Parasitology. 2010 Feb;137(2):311-20
• All: 1 reference(s)